What's the deal with CBD Oils and Creams? Do they contain THC?

Contributed by Anna Filardo, Education Program Manager

Cannabis|noun|can•na•bis|\’ka-nә-bәs\: any of the preparations (as marijuana or hashish) or chemicals (as THC) that are derived from the hemp plant and are psychoactive.¹

Essentially, marijuana is a species of cannabis, specifically named Cannabis Indica or Cannabis Sativa. There are more than 100 different cannabinoids that make up the marijuana plant; the most widely known are Δ9-tetrahydrocannabinol (or THC) and cannabidiol (or CBD). THC is commonly attributable to the psychoactive or euphoric side effects, while CBD is known for its more medicinal effects. Marijuana (specifically THC) is banned by a majority of sports organizations and is not eligible for medical exceptions or therapeutic use exemptions (TUEs). So what about CBD?

Recently, CBD oils and creams available for purchase in stores or on the internet have been growing in popularity, as seen in an increase of Drug Free Sport AXIS™ inquiries for these products. CBD has been cited for having some medicinal benefits, and homeopathic doctors are prescribing CBD oils and creams for treatment. The Drug Enforcement Administration (DEA) classifies CBD extract as a Schedule I Controlled Substance, which means it is illegal in states that have not passed medical marijuana laws.²

Manufacturers may claim their products are “pure CBD” and do not contain THC. However, there is no way to be certain the products do not also contain THC. The DEA asserts that it is “not aware of any industrially-utilized methods that have achieved this result [of 100% CBD].” ²  In February of 2016, the US Food and Drug Administration (FDA) tested the composition of 22 CBD tinctures, oils, and creams. A majority of the products were marketed to be “100% Pure CBD.” Upon testing, the FDA found that almost all of the products tested did not have the amount of CBD claimed; some products did not contain any CBD, while others contained far less. THC was also present in measurable amounts in most of the products.³

CBD products are not approved by the FDA for marketing or distribution as safety and effectiveness have not been proven, and the federal government classifies marijuana as an illegal substance. Therefore, the FDA does not test these products before they are available to consumers. Since the FDA does not test CBD products before becoming available to consumers, there is no way to tell the amount of CBD (or THC) in each product. Therefore, AXIS classifies CBD oils and creams as high risk products. 

Dr. David Kuntz, Ph.D., Executive Director of Analytical Toxicology for Clinical Reference Laboratories, affirms 

“Plants are being specifically developed to have high concentrations of CBD to maximize the compound in the bud.  It is my understanding that there are no 100% pure CBD products on the market, and these products will contain minor to significant amounts of THC in the oil depending on their purification steps.”

Bottom line: The use of CBD oils, creams or tinctures may cause adverse health effects and/or a positive drug test.

To learn more about the difference between THC and CBD, view this short video and check out the new Marijuana tab on Drug Free Sport AXIS™. 

Sources:

      Definition of Cannabis, Merriam-Webster

      Establishment of a New Drug Code for Marihuana Extract

      2016 Warning Letters and Test Results for Cannabidiol-Related Products

 

Other Resources:

• Committee on the Health Effects of Marijuana. (2017). The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research. National Academies of Sciences, Engineering, Medicine.
• Video: CBD is Schedule I and always has been

Vaping: What's it all about?

Contributed by Anna Filardo, Education Program Manager

Image Credt: fda.gov (1)

Vaping has continued to increase in use and popularity. New federal regulations have recently been established and research on long-term use of vaporizers is growing. This post presents current information and potential dangers of vaping.

• Electronic Nicotine Delivery Systems (ENDS) go by various names.

• Vaporizer, vape pens, hookah pens, electronic cigarettes (e-cigarettes), and e-pipes.(1)

• "E-Liquids" (the fluid mixture that is vaporized) vary, and may include:

• Nicotine, marijuana, propylene glycol, and/or flavored glycerin are most common.(1)
• Formaldehyde or acetaldehyde have also been found.(2)
• Ethanol (or alcohol) is frequently used and could lead to a future alcohol dependence. (4)
• Toxic metal nanoparticles from the vaping mechanism.(3)

• ENDS vs. Cigarette Smoking.

• Teens that vape are more susceptible to take up cigarette smoking.(4)
• Informative Video from ASAPScience: Smoking vs. Vaping

• Long-term health consequences remain unclear.

• Users may suffer from "Popcorn Lung", due to the presence of diactetyl.(5)
• "The brain is the last organ in the human body to develop fully. Nicotine exposure during periods of significant brain development, such as adolescence, can disrupt the growth of brain circuits that control attention, learning, and susceptibility to addiction." -U.S. Surgeon General Dr. Vivek Murthy (6)

• The FDA has recently gained regulatory authority over ENDS, beginning August 2016.(1)

• It will take up to 2 years for the FDA to fully evaluate all 500 brands and 7,700 e-liquid flavors.(7) 

• Vaporizers can be used to mask the smell of marijuana.

• Marijuana concentrates or "hash oil" (which can contain up to 90% THC) can be added to e-liquid.(8)
• "Pure CBD Oil" for vape pens is easily purchased via the internet. Video: CBD vs. THC

*Image of actual product submitted to Drug Free Sport AXIS™.

ENDS & Vaping Resources:

1. U.S. Food & Drug Administration: Vaporizers, E-Cigarettes, and other Electronic Nicotine Delivery Systems (ENDS)
2. Oxford Academic: Nicotine & Tobacco Research
3. National Institute on Drug Abuse: Electronic Cigarettes (e-Cigarettes)
4. ScienceNews for Students: Teen data find vapors often become smokers
5. American Lung Association: Popcorn Lung; A Dangerous Risk of Flavored E-Cigarettes
6. E-Cigarette Use Among Youth and Young Adults: A Report of the Surgeon General
7. American Lung Association: E-Cigarettes and Lung Health
8. NPR: Pot Smoke And Mirrors: Vaporizer Pens Hide Marijuana Use
9. CDC: E-Cigarettes and Young People: A Public Health Concern
10. Know the Risks: E-Cigarettes and Young People
11. Tips for Talking About E-cigarettes

Testosterone Boosters

Dietary supplements claiming to boost testosterone or enhance sexual performance are often explored and inquired about by athletes. However, these products come with concerns. Many of the ingredients are created in factories, making them unnatural, and lack scientific evidence regarding their safety and efficacy, even if the products are labeled as “herbal” or “all natural” (Campbell et al., 2013).

The Food and Drug Administration (FDA) holds dietary supplement manufacturers responsible for truth in labeling and safety of all dietary supplement products that enter the consumer market. Unfortunately, these companies may not list each product ingredient on the supplement facts panel, can make false or exaggerated claims, and/or add harmful ingredients. Due to the unregulated nature of supplements, there is little data regarding the products as a whole, including the ingredients, use of proprietary blends, and marketing claims (Willoughby, Spillane, & Schwarz, 2014).

Testosterone boosters and sexual enhancement products have a higher risk of containing harmful ingredients that are not listed on the label, compared to other supplement categories. For example, phosphodiesterase type 5 (PDE5) inhibitors are pharmaceutical medications used to treat erectile dysfunction. PDE5 inhibitors have been found in testosterone boosting and sexual enhancement supplements, but have not been listed on the product label. In 2013, researchers tested sexual performance supplements to determine if they were adulterated with PDE5 inhibitors or other undeclared ingredients. The marketing for all 54 tested supplements claimed they did not contain synthetic substances. However, 81% of the tested products contained one or more synthetic PDE5 inhibitor or similar ingredient, undisclosed to the consumer (Campbell et al., 2013).

Taking dietary supplements that “boost testosterone” have proven ineffective in reducing fat mass, as well as increasing total body or muscle mass. Instead, products making these claims come with a lot of unknowns and dangers (Willoughby et al., 2014).

Consumers are made to believe that testosterone levels and muscle mass will increase with the use of dietary supplements claiming to be testosterone boosters. Manufacturers even state that their product is scientifically proven to work. When in reality, they often contain dietary ingredients that have not been tested for efficacy or safety.

Tribulus terrestris (TT) is a popular herbal ingredient found in testosterone boosting supplements. TT is associated with claims of boosting testosterone and correcting erectile function. Physically-active men are the target market for products containing TT (Pokrywka, 2014). Similarly, TT allegedly improves plasma testosterone levels and increases skeletal muscle growth (Antonio, Uelmen, Rodriguez, & Earnest, 2000). The use of dietary supplements with TT has shown no substantiated benefits in human studies. As with most dietary ingredients, there is a lack of evidence-based information regarding the effectiveness and safety of TT use in sport (Pokrywka, 2014). The consumer should be aware that many herbal/all-natural ingredients claiming to boost testosterone levels or provide other anabolic effects have limited scientific support.

Drug Free Sport believes that food should be the first option for fueling when athletes are looking to reach performance goals. Dietary supplements are poorly regulated by the FDA, with manufacturers loosely following the FDA’s guidelines. Supplement companies market their products how they wish, often place unlabeled ingredients in the bottle, and make false claims. Appropriately-timed meals and snacks, on the other hand, have been proven to aid in weight reduction and achieving sports performance goals.

If you are thinking about taking any dietary supplement, please visit Drug Free Sport AXIS™ to learn more about your options to make an informed decision. 

References:

Antonio, J., Uelmen, J., Rodriguez, R., & Earnest, C. (2000). The effects of tribulus terrestris on body composition and exercise performance in resistance-trained males. International Journal of Sport Nutrition and Exercise Metabolism, 10, 208-215.

Campbell, N., Clark, J.P., Stecher, V.J., Thomas, J.W., Callanan, A.C., Donnelly, B.F.,… Kaminetsky, J.C. (2013). Adulteration of purported herbal and natural sexual performance enhancement dietary supplements with synthetic phosphodiesterase type 5 inhibitors. International Society for Sexual Medicine, 10, 1842-1849.

Pokrywka, A., Obminski, Z., Malczewska-Lenczowska, J., Fijatek, Z., Turek-Lepa, E., & Grucza, R. (2014). Insights into supplements with tribulus terrestris used by athletes. Journal of Human Kinetics, 41, 99-105.

Qureshi, A., Naughton, D.P., & Petroczi, A. (2014). A systematic review on the herbal extract tribulus terrestris and the roots of its putative aphrodisiac and performance enhancing effect. Journal of Dietary Supplements, 11(1), 64-79.

Willoughby, D.S., Spillane, M., & Schwarz, N. (2014). Heavy resistance training and supplementation with the alleged testosterone booster NMDA has on effect on body composition, muscle performance, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained males. Journal of Sports Science and Medicine, 13, 192-199.

Supplement Certification Programs: State of the Industry and What You Need to Know

Dietary supplement (DS) contamination is a growing concern amongst sports organizations, defined as adding ingredients unlisted on the nutrition label into the supplement. DS are growing in popularity amongst athletes of all levels. However, little is known about these items that are being ingested by athletes. What is really in this supplement and is it banned?  

DS have a lot of unknown variables, due to a lack of government or industry regulation. Most sports organizations do not condone the use of DS, with intentions of protecting an athlete’s health and safety. The Food and Drug Administration (FDA) currently does not regulate DS; therefore, anyone can make a dietary supplement without content restrictions. Many DS can be contaminated with Selective Androgen Receptor Modulators (SARMs), substances that act like steroids. Without knowledge of these ingredients, athletes perceive the DS as harmless. In fact, it’s often quite the contrary. SARMS are strictly banned by most sports organizations, with a positive drug test due to banned substances bringing many perilous consequences.

Third-Party Supplement Certification Programs are fighting to ensure that all DS are safe to use and true to their labels. Meaning, DS companies are not hiding banned ingredients in their products. An excellent educational option for third-party supplement certification programs is the upcoming Sport Exchange Summit, Powered by Drug Free Sport. John Travis (Senior Research Scientist, National Science Foundation), Dave Ellis (first President of the Collegiate and Professional Sports Dietitians Association), and Dr. Dan Fabricant (Executive Director and CEO, Natural Products Association) will address the “what’s” and “why’s” of third-party supplement certification programs that are striving to clean up the supplement industry for athletes and general consumers. From the shared expertise of the panel, attendees will better understand the dynamics of banned substance testing, recognize products of concern, and begin to develop feasible approaches to help athletes make informed decisions about sports supplements.

Drug Free Sport’s Resource Exchange Center (REC) is the premier supplement review resource for NCAA, NAIA, LPGA, PGA Tour, USA Track & Field, and VADA sports organizations. The REC researches supplements submitted for contamination issues along with recalls, working to ensure health and safety of all of our clients’ athletes.

Don’t miss your chance to learn about third-party supplement certification programs at the Sport Exchange Summit, Powered by Drug Free Sport. Early-bird registration has been extended until the end of May! Register today at sportexchangesummit.com to educate yourself via industry leaders.

For more information on dietary supplement safety, visit dfsrec.com.